Curriculum Vitae

Download a PDF of Dr. Crisp’s CV

Contents:

  1. Education
  2. Professional Experience
  3. Awards/Honors
  4. Professional Organizations
  5. Institutional Standing Committees
  6. Institutional Ad Hoc Committees
  7. Professional Activities
  8. Grant Support (Funded)
  9. Research Interests
  10. Publications
  11. Invited Reviews
  12. Abstracts
  13. Doctoral and Masters Dissertation/Thesis Committees
  14. Faculty Research Mentor (College of Osteopathic Medicine), Des Moines University
  15. Faculty Research Mentor (College of Podiatric Medicine and Surgery), Des Moines University
  16. Des Moines University Research Mentor, Biomedical Sciences Graduate Program

I. Education

1985 Ph.D., Biomedical Science (Pharmacology); Marshall University School of Medicine, Huntington, WV in cooperation with the Robert C. Byrd Health Sciences Center, Morgantown, WV.
1982 M.S., Human Development and Psychology; University of Texas at Dallas, Richardson, TX.
1980 B.A., Psychology; University of Texas – Pan American, Edinburg, TX.

II. Professional Experience

Present Crisp Enterprises: Pharmacology Instruction and Consultation, LLC
Present Becker Professional Education, USMLE Step-1 Pharmacology Review Courses
Present Adjunct Professor, College of Professional Studies and College of Graduate Studies, Indiana Wesleyan University, Advanced Pharmacology, Marion, Indiana.
1/13 – Present USMLE Step-1 Pharmacology Instructor, Becker Professional Education
5/07 – 2013 USMLE Step-1 Pharmacology Instructor, Kaplan Medical
01-2010 Professor and Chair, Department of Physiology and Pharmacology, Des Moines University, Des Moines, IA.
07-2010 Faculty Joint Appointment, Department of Medical Humanities and Bioethics, Des Moines University
1997 – 01 Course Director, Medical Pharmacology, Northeastern Ohio Universities College of Medicine (NEOUCOM), Rootstown, OH.
1993 – 99 Associate Director, School of Biomedical Sciences, Kent State University and NEOUCOM, Rootstown, OH.
1993 – 99 Director of Graduate Studies, NEOUCOM, Rootstown, OH.
1992 – 01 Associate Professor, Department of Neurobiology and Pharmacology, NEOUCOM, Rootstown, OH.
1987 – 92 Assistant Professor, Department of Neurobiology and Pharmacology, NEOUCOM, Rootstown, OH.
1985 – 87 Postdoctoral Research Associate, Department of Anesthesiology, Robert C. Byrd Health Sciences Center, West Virginia University Morgantown, WV.

III. Awards/Honors

  • Outstanding Faculty Award, Northeastern Ohio Universities College of Medicine (NEOUCOM), 1990, 1991, 1992, 1993, 1994, 1995, 1996, 1997, 1998, 1999, 2000, 2001
  • Faculty President, Des Moines University (DMU): 2006-2007
  • DMU Outstanding Teacher Award: 2007
  • Basic Science Teacher of the Year Award, DMU College of Osteopathic Medicine: 2005, 2007
  • Dean’s Award for Teaching Excellence: 2006
  • Basic Science Faculty of the Year Award, DMU College of Podiatric Medicine and Surgery: 2003, 2005, 2007, 2010
  • Preclinical Faculty of the Year Award, DMU Physician Assistant Program: 2005
  • Liebelt/Wheeler Award for Faculty Excellence (NEOUCOM): 1993
  • American Medical Women’s Association Gender Equity Award: 1997

IV.  Professional Organizations

  • Society for Neuroscience (1985-present)
  • American Pain Society (1989-1996; 2003-present)
  • International Association for the Study of Pain (1989-present)
  • American Society for Pharmacology and Experimental Therapeutics (ASPET; 1989-present)
  • ASPET 2003 Nominating Committee (Neuropharmacology Division)
  • Association of American Medical Colleges Graduate Research, Education and Training

V.  Institutional Standing Committees

A. Des Moines University, August, 2001 – 2010

07/02-06/10         Chair, College of Osteopathic Medicine Admissions Committee (COM)

09/09-12/10         Higher Learning Commission Steering Committee

09/09-12/10         Appointment as Writer, Higher Learning Commission Accreditation Self-Study

07/09-12/10         Student Promotion and Evaluation Committee, College of Osteopathic Medicine

09/01-12/10         DMU College of Osteopathic Medicine Scholarship Committee

08/01-12/10         University Graduate Council (Chair July, 2005 – present)

07/02-06/05         DMU Rank, Promotion and Tenure Committee

07/07-06/10         DMU Rank, Promotion and Tenure Committee

07/02-06/08         DMU Institutional Animal Care and Use Committee

07/03-06/08         Curriculum Committee, College of Podiatric Medicine and Surgery

07/05-06/08         University Facilities Committee (Chair, 2005)

07/06-06/08         Post-Professional Doctor of Physical Therapy Diversity Scholarship Committee

07/06-06/07         Faculty President, Des Moines University

01/07-12/10         Professionalism Task Force

07/07-12/10         Strategic Planning Committee (Chair), College of Osteopathic Medicine

06/06-12/10         Faculty Peer Evaluation Committee

09/01-06/04         Affirmative Education Committee

B. NEOUCOM, October, 1987 – July, 2001

03/90-06/92         Academic Council

07/98-06/99         Academic Council

05/88-06/92         Library Committee

07/93-06/95         Honorary Degree Committee

05/88-08/96         Peer/Faculty Advisor

10/87-06/01         Pharmacology Program Committee (Chair; 1989-1996)

10/87-06/01         Neuroscience Program Committee

06/90-07/99         Executive Committee, School of Biomedical Sciences, KSU

05/90-05/99         Graduate Coordinating Committee (Chair; 1993-2001)

06/88-06/00         Academic Review and Promotions (Vice Chair,1995-2000)

08/96-06/01         Professional Development and Advising Team

01/96-06/01         BS/MD Admissions Committee, University of Akron/NEOUCOM

07/96-06/99         Institutional Animal Care and Use Committee (IACUC)

07/96-06/99         Tenure Committee

04/98-06/01         M1/M2 Curriculum Committee


VI.  Institutional Ad Hoc Committees

A. Des Moines University, Ad Hoc, August, 2001 – present

09/01-08/02     Curricular Implementation Task Force

01/02-01/03     Biochemistry Search Committee

10/01-0/6-01    Pharmacology Search Committee (Chair)

10/01-09/03     Physiology Search Committee (Chair)

10/01-05/02     Problem-Based Learning Facilitator

01/02-07/03     Family Medicine Search Committee

09/01-05/02     Iowa Osteopathic Educational Foundation (IOEF) Summer Research Fellowship

09/01-06/05     Advisory Board, Geriatric Education Center

01/03-12/03     Search Committee, Director of Physical Therapy

07/04-01/05     Search Committee, Assistant Professor, Biochemistry and Nutrition

01/05-06/05     Search Committee, Internal Medicine Clinical Faculty Member

09/05-02/06     Search Committee, Associate Dean of Clinical Affairs/Site Development (Chair)

05/06-05/07     Search Committee, Executive Associate Dean for Clinical Affairs

11/07-06/08     Search Committee, Asst. Prof. Osteopathic Manipulative Medicine

B. NEOUCOM, October, 1987 – July, 2001

08/89-01/90     Search Committee, Assistant Professor, Department of Pharmacology

01/90-06/90     Search Committee, Chair, Department of Anatomy

01/91-09/91     Search Committee, Assistant Professor, Department of Pharmacology

02/91-01/92     Search Committee, President/Dean, NEOUCOM

11/92-06/93     Academic Review and Promotion Guidelines and Handbook Committee

09/92-09/94     Interdisciplinary Geriatric Task Force

01/94-07/94     Search Committee, Assistant Professor, Department of Pharmacology

01/94-08/94     Review of the Procedures for the Award and Denial of Tenure

01/95-06/96     LCME Subcommittee for Graduate Education in the Basic Medical Sciences

04/95-05/96     Search Committee, Director, Division BMS, Assoc. Dean for Research

01/96-01/98     Search Committee for Chair, Biochemistry and Molecular Pathology

01/96-06/96     Biochemistry and Molecular Pathology Departmental Review Committee

11/97-03/98     Physiology Departmental Review Committee

03/98-07/98     Search Committee for Chair, Department of Emergency Medicine

09/98-09/99     Search Committee, 2 Assistant Professors, Department of Neurobiology

11/98-07/99     Departmental Reorganization Committee, Basic Medical Sciences

11/98-01/00     NEOUCOM Tenure Review Process

03/98-06/01     Medical Problems (Problem-Based Learning) Facilitator

07/99-02/00     Search Committee, Assistant Professor, Department of Physiology

07/99-02/00     Search Committee, Chair, Department of Internal Medicine


VII.  Professional Activities

A. Journals Reviewed/Refereed

  1. Journal of Pharmacology and Experimental Therapeutics
  2. Pharmacology Biochemistry and Behavior
  3. Life Sciences
  4. Brain Research
  5. Pharmacology Letters
  6. Analgesia
  7. Pain
  8. European Journal of Neuroscience
  9. Behavioral Brain Research
  10. Neurobiology of Aging
  11. Neuroscience Letters

B. NIH Study Sections, Grant Reviews and National/International Service

  • National Institutes of Health, Fellowship Study Section: Sensory, Motor and Cognitive
  • Neuroscience (full member)
  • Neurotoxicity and Alcohol Study Section, NIH Integrative, Functional and Cognitive
  • Neuroscience (ad hoc)
  • Special Emphasis Panel of the Brain Disorders and Clinical Neurosciences; NIH/CSR
  • National Institute on Drug Abuse (Pharmacology Research Committee; ad hoc)
  • Department of Veterans Affairs, VA Merit Review Board, ad hoc
  • National Institute on Drug Abuse (Neurophysiology/Neuroanatomy Res. Comm. ad hoc)
  • Spinal Cord Research Foundation, Paralyzed Veterans of America, ad hoc
  • The Wellcome Trust, London, ad hoc
  • National Science Foundation, ad hoc
  • Item writer, National Board of Osteopathic Medical Examiners (NBOME)
  • Item writer, National Board of Podiatric Medical Examiners (NBPME)
  • Institutional Review Board (IRB), Methodist/Lutheran & Blank Children’s Hospital

VIII.  Grant Support (Funded)

Iowa Osteopathic Education and Research Grant, T. Crisp, P.I., 20% effort, Oxidative Stress, Peripheral Nerve Injury and Persistent Pain. (December, 2007 – December 30, 2009) $10,950.

Iowa Osteopathic Education and Research Grant, T. Crisp, P.I., 20% effort Reversal of Neuropathic Pain with Combination Pharmacotherapy (January, 2006 – December 30, 2007); $12,600.

Iowa Osteopathic Education and Research Grant, T. Crisp, P.I., 20% effort, Aging and the Pharmacotherapy of Neuropathic Pain (January 15, 2004 – December 30, 2005); $10,000.

Iowa Osteopathic Education Foundation, T. Crisp, P.I., 20% effort, Aging, Oxidative Stress and Nociception (October/2001-May, 2004); $106,920 (start-up funding).

National Institutes of Health, William L.R. Cruce, P.I., Terriann Crisp, Co-Investigator (10%) and Sherry L. Stuesse, Co-Investigator (20%), Thermal Hyperalgesia in Aged Rats (July/99-6/01); $72,469.

National Institute on Aging, Terriann Crisp, P.I.  Age-Related Changes in Spinal Opiate-Induced Analgesia (April/1992 –  March/1998); $478,770.

Ohio Research Challenge Grant (Intramural), Effects of Age on Morphological Determinants of Neuronal Activity.  (6/2000 – 5/2001; $20,000).  Sherry L. Stuesse, P.I., Terriann Crisp, co-Investigator (10%) and William L.R. Cruce, co-Investigator (10%).

Ohio Research Challenge Grant (Intramural), Neurochemical Mechanisms Underlying Chronic Neuropathic Pain: Effects of Aging and Gender (August 1, 1998 – January, 2000; $19,699).  Sherry L. Stuesse, co-Investigator.

Research Continuance Grant, Mechanisms of Neuropathic Pain (April 20, 1998-01); $52,405.

Associates in Anesthesiology, Western Reserve Care System, Youngstown, Ohio, The Mechanism Underlying Spinal Opiate-Induced Analgesia (Multiple Year Funding)

  • Mar. 1, 1988 – Feb. 28, 1989, $25,000
  • Mar. 1, 1989 – June 30, 1990, $25,000
  • July 1, 1990 – Feb. 28, 1991, $25,000
  • Mar. 1, 1991 – Feb. 28, 1992, $30,000
  • Jun. 1, 1993 – May 31, 1996, $29,000

Ohio Research Challenge Grant, The Analgesic Properties of Spinal Excitatory Amino Acid Antagonists in the Rat (May 1, 1994 – June 30, 1995); $7,500

Ohio Research Challenge Grant, Age-Related Changes in Spinal Opiate-Induced Analgesia (July 1, 1992 – June 30, 1993); $3,044.

Western Reserve Care System, Youngstown, Ohio,  The Effects of Aging on Spinal Opiate-Induced Analgesia and Tolerance (Oct. 15, 1991 – Dec. 15, 1992); $3,000.

Western Reserve Care System, Youngstown, Ohio,  Further Characterization of Opioid Receptor Sites in the Rat Spinal Cord (Oct. 15, 1991 – Dec. 15, 1992); $3,300.

Ohio Research Challenge Grant,  Spinal Serotonin Receptor-Mediated Antinociception (February, 1990 – June 30, 1991); $5,530.

American Federation For Aging Research, Terriann Crisp, P.I., Age-Related Changes in Spinal Opiate-Induced Analgesia (July 15, 1989 – September 1, 1990); $23,400.00.

Western Reserve Care System, Youngstown, Ohio,  Spinal Antinociceptive Actions of DAMPGO, DPDPE and Morphine Sulfate in an Animal Model of Chronic Pain (June 1, 1989 -January 1, 1990); $2,500.

The Department of Gerontology/Geriatric Medicine, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio.  The Monoaminergic Involvement of Spinal Opiate-induced Analgesia (May 15, 1988 – August 31, 1989); $5,500.

Biomedical Research Support Grant #2S07 RR 05806-09,  The Analgesic Effectiveness of Spinal Opiates (Jan. 1, 1988 – Dec. 31, 1988); $5,000.

Ohio Research Challenge Grant,  Neurotransmitter Involvement in Spinal Opiate Action (April 1, 1988 – December 1, 1988); $4,718.


IX.  Research Interests

Primary areas of research included investigating:

  1. Age-related differences in the perception and treatment of acute and chronic pain disorders; and
  2. The role of oxidative stress in chronic neuropathic pain disorders.  The goal of these experiments was to determine if antioxidants were efficacious for the treatment of chronic neuropathic pain disorders.

X.  Publications

Crisp, T.: USMLE Step-1 Pharmacology Review Flash Card Series. High yield review of the medical pharmacology principles and drugs most likely to appear on the USMLE. Lange, McGraw-Hill Education, 2014.

Crisp, T. and Finnerty, E.P.: Antiallodynic efficacy of combination opiate and antioxidant treatment.  In Preparation (2011).

Crisp, T. and Finnerty, E.P.:  Reversal of tactile-evoked allodynia with combination pharmacotherapy with morphine and α-lipoic acid.  In Preparation (2011).

Crisp, T., Minus, T.O., Coleman, M.L., Giles, J.R., Cibula, C. and Finnerty, E.P.: Aging and peripheral nerve injury:  Effects of the antioxidant 16-desmethyltirilazad. Behavioral Brain Research, 166: 159-165, 2006.

Tall, J.M., and Crisp, T.: The effects of sex and gonadal hormones on nociceptive responses to intraplantar carrageenan in the rat.  Neuroscience Letters, 354: 239-241, 2004.
Crisp, T., Giles, J.R., Cruce, W.L.R., McBurney, D.L. and Stuesse, S.L.: The effects of aging on thermal hyperalgesia and tactile-evoked allodynia using two models of peripheral mononeuropathy in the rat.  Neuroscience Letters, 339: 103-106, 2003.

Tall, J.M., Stuesse, S.L., Cruce, W.L.R. and Crisp, T.: Gender and the behavioral manifestations of neuropathic pain.  Pharmacol Biochem Behav 68: 99-104, 2001.

Cruce, W.L.R., Lovell, J.A., Crisp, T. and Stuesse, S.L.: Effect of aging on the substance P receptor, NK1, in the spinal cord of rats with peripheral nerve injury.  Somatosensory and Motor Res. 18 (1): 66-75, 2001.

Stuesse, S.L., Crisp, T., McBurney, D.L., Schechter, J.B., Lovell, J.A. and Cruce, W.L.R.: Neuropathic pain in aged rats: behavioral responses and astrocytic activation.  Exp. Brain Res., 137: 219-227, 2001.

Lovell, J.A., Stuesse, S.L., Cruce, W.L.R. and Crisp, T.: Strain differences in neuropathic hyperalgesia.  Pharmacol Biochem Behav, 65: 141-144, 2000.

Schechter, J.B. and Crisp, T.: Secure cranial-mount intrathecal cannulation – a spinal administration technique in the rat.  Journal of Neurosci. Methods, 97: 31-35, 2000.

Lovell, J.A., Novak, J.C., Stuesse, S.L., Cruce, W.L.R. and Crisp, T.: Changes in spinal serotonin turnover mediate age-related differences in the behavioral manifestations of peripheral nerve injury.  Pharmacol Biochem Behav, 66: 873-878, 2000.

Stuesse, S.L., Cruce, W.L.R., Lovell, J.A., McBurney, D.L. and Crisp, T.: Microglial proliferation in the spinal cord of aged rats with a sciatic nerve injury.  Neurosci. Lett., 287: 121-124, 2000.

Novak, J.C., Lovell, J.A., Stuesse, S.L., Cruce, W.L.R., McBurney, D.L. and Crisp, T.: Aging and neuropathic pain. Brain Res., 833: 308-310, 1999.

Hoskins, D.L., Gordon, T.L. and Crisp, T.: The effects of aging on mu and delta opioid receptors in the spinal cord of Fischer-344 rats. Brain Res. 791: 299-302, 1998.

Ko, M.L., King, M.A., Gordon, T.L. and Crisp, T.: The effects of aging on spinal neurochemistry in the rat.  Brain Res. Bull. 42: 95-98, 1997.

Smith, D.J., Monroe, P.J., Kirk, H.R., Crisp, T. and Smith, D.L.:  Pharmacological evaluation of neuronal mechanisms involved in spinal antinociception may be confounded by a lack of drug specificity: An analysis using opioid and monoaminergic interactions.  Analgesia 2: 31-41, 1996.

Keck, B.J., Stafinsky, J.L., Uram, M. and Crisp, T.:  A lack of supersensitivity to opioid receptor agonists following chronic spinal opioid receptor antagonist administration in the rat. Gen. Pharmac. 26: 161-168, 1995.

Crisp, T., Stafinsky, J.L., Hoskins, D.L., Dayal, B., Chinrock, K., and Uram, M.:  The effects of aging on spinal opiate-induced antinociception.  Neurobiol. Aging, 15: 169-174, 1994.

Crisp, T., Stafinsky, J.L., Hoskins, D.L., Perni, V.C., Uram, M. and Gordon, T.:  Age-related changes in the spinal antinociceptive effects of DAMPGO, DPDPE and ß-endorphin in the rat.  Brain Res., 643: 282-286, 1994.

Crisp, T: Adrenergic Drugs.  In: Basic Pharmacology in Medicine.  ed., E.J. Barbieri (Section Editor), Hahnemann University, 1994.

Crisp, T., Stafinsky, J.L., Perni, V.C. and Uram, M.:  The noradrenergic component contributing to spinal fentanyl-induced antinociception is supraspinally mediated.  Gen. Pharmac., 23: 1087-1091, 1992.

Calcagnetti, D.J., Stafinsky, J.L. and Crisp, T.:  A single restraint stress exposure potentiates analgesia induced by intrathecally administered DAGO.  Brain Res., 592: 305-309, 1992.

Crisp, T., Stafinsky, J.L., Spanos, L.J., Uram, M., Perni, V.C. and Donepudi, H.B.: Analgesic effects of serotonin and receptor-selective serotonin agonists in spinal cord.  Gen. Pharmac., 22: 247, 1991.

Crisp, T., Perrotti, J.M., Smith, D.L., Stafinsky, J.L. and Smith, D.J.: The local monoaminergic dependency of spinal ketamine. Eur. J. Pharmacol., 194: 167, 1991.

Crisp, T., Stafinsky, J.L., Uram, M., Perni, V.C., Weaver, M.F. and Spanos, L.J.: Serotonin contributes to the spinal antinociceptive effects of morphine.  Pharmacol. Biochem. Behav., 39: 591, 1991.

Monroe, P.J., Perschke, S.E., Crisp, T. and Smith, D.J.: Evaluation of the interactions of serotonergic and adrenergic drugs with μ, δ and κ opioid binding sites.  Neurosci. Lett., 133: 229-232, 1991.

Smith, D.J., Pekoe, G.M., Monroe, P.J., Martin L.L., Cabral, M.E.Y. and Crisp, T.: Ketamine analgesia in rats may be mediated by an interaction with opiate receptors.  In: Status of Ketamine in Anesthesiology. NPP Books, Ed., E.F. Domino, Ann Arbor, MI, 199-210, 1990.

Crisp, T., Stafinsky, J.L., Hess, J.E. and Uram, M.:  Spinal ß-endorphin analgesia involves an interaction with local monoaminergic systems.  Eur. J. Pharmacol., 160: 211, 1989.

Crisp, T., Stafinsky, J.L., Boja, J.W. and Schechter, M.D.: The antinociceptive effects of 3,4 methylenedioxymethamphetamine (MDMA) in the rat.  Pharmacol. Biochem. Behav., 34: 497, 1989.

Crisp, T., and Smith, D.J.: A local serotonergic component involved in the spinal antinociceptive action of morphine. Neuropharmacology., 28: 1047, 1989.

Spanos, L.J., Stafinsky, J.L. and Crisp, T.: A comparative analysis of monoaminergic involvement in the spinal antinociceptive action of DAMPGO and DPDPE.  Pain, 39: 329, 1989.

Smith, D.J., Perrotti, J.M., Crisp, T., Cabral, M.E.Y., Long, J. T. and Scalzitti, J.M.: The : opiate receptor is responsible for descending pain inhibition originating in the periaqueductal gray region of the rat brain.  Eur. J. Pharmacol., 156: 47-54, 1988.

Smith, D.J., Bouchal, R.S., de Sanctis, C.A., Monroe, P.J., Amedro, J.B., Perrotti, J.M. and Crisp, T.:  Properties of the interaction of ketamine at opiate binding sites in vivo and in vitro.  Neuropharmacology., 26: 1253-1260, 1987.

Trulson, M.E. and Crisp, T.:  Do serotonin-containing dorsal raphe neurons possess autoreceptors?  Exp. Brain Res. 62: 579-586, 1986.

Trulson, M.E., Crisp, T. and Henderson, L.J.:  Ascorbic acid antagonizes the behavioral effects of LSD in cats.  J. Pharm. Pharmacol. 37: 930-931, 1985.

Trulson, M.E. and Crisp, T.:  Role of norepinephrine in regulating the activity of serotonin-containing dorsal raphe neurons.  Life Sci. 35: 511-515, 1984.

Trulson, M.E., Crisp, T. and Trulson, V.M.:  Activity of serotonin-containing nucleus centralis superior (raphe medianus) neurons in freely moving cats.  Exp. Brain Res. 54: 33-44, 1984.

Trulson, M.E. and Crisp, T.:  Behavioral effects of serotonergic and dopaminergic drugs in cats following chronic amphetamine administration.  Eur. J. Pharm. 99: 313-324, 1984.

Trulson, M.E., Crisp, T. and Henderson, L.J.:  Mescaline elicits behavioral effects in cats by an action at both serotonin and dopamine receptors.  Eur. J. Pharmacol. 96: 151-154, 1983.

Trulson, M.E., Crisp, T. and Trulson, V.M.:  Dopamine-containing substantia nigra units are unresponsive to changes in plasma glucose levels induced by dietary factors, glucose  infusions or insulin administration in freely moving cats.  Life Sci. 32: 2555-2564, 1983.

Trulson, M.E., and Crisp, T.:  Tolerance develops to LSD while the drug is exerting its maximal behavioral effects:   Implications for the neural bases of tolerance.  Eur. J.  Pharmacol. 96: 317-320, 1983.

Trulson, M.E. and Crisp, T.:  Behavioral and neurochemical effects of apomorphine in the cat.  Eur. J. Pharmacol. 80: 295-309, 1982.

Trulson, M.E. and Crisp, T.:  Lack of synergism and cross tolerance between tactile stimulus and LSD-induced limb flicking in the cat. Pharmacol. Biochem. Behav. 17: 91, 1982.

Trulson, M.E., Crisp, T. and Howell, G.A.:  Raphe unit activity in freely moving cats:  Effects of quipazine.  Neuropharmacology 21: 681-686, 1982.

Trulson, M.E., Bradstetter, J.W., Crisp, T. and Jacobs, B.L.: Behavioral effects of quipazine in the cat. Eur. J. Pharmacol., 78: 295-305, 1982.


XI.  Invited Reviews:

Larsen, B. and Crisp, T.: New perspectives for treating insulin-dependent diabetes mellitus: Novel therapies and protocols. Invited review, Sociedad Iberoamericana de Informacion Cientifica (SIIC), 2002.


XII.  Abstracts:

Crisp, T., Giles, J.R., Egli, S. D., Henry, M.K. and Finnerty, E.P.: Aging and the antiallodynic efficacy of combination treatment with opiates and antioxidants.  (FASEB, 2008).

Crisp, T., Giles, and Finnerty, E.P.: Opiates and antioxidants inhibit tactile-evoked allodynia.  The FASEB Journal, Vol. 21, No. 5, A412, April, 2007.

Crisp, T., Giles, J.R., Beenken, T.R., Cannon, K.A. and Finnerty, E.P.: Combination pharmacotherapy with opiates and antioxidants inhibits tactile-evoked allodynia in rats. 9th International Conference on the Mechanisms and Treatment of Neuropathic Pain, Bermuda, 2006.

Crisp, T., Giles, J.R., Cibula, C. and Gillen, A.: Aging, peripheral nerve injury and antioxidants.  The Journal of Pain (Supplement), 5 (3) 55, 2004.

Crisp, T., Aging and the behavioral manifestations of peripheral nerve injury.  Symposium: Mechanisms of Pain in Later Life: Evidence from Animal and Human Experimental and Clinical Models, American Pain Society/Canadian Pain Society, Vancouver, 2004.

Crisp, T., Shelley, B.C., Hanson, M.L., Minus, T.O., Giles, J.R. and Finnerty, E.P.: Effects of pre- versus post-treatment of neuropathic pain symptoms with antioxidants. Sixth International Conference on the Mechanisms and Treatment of Neuropathic Pain, San Francisco, CA, 2003.

Crisp, T., Minus, T.O., Hanson, M.L. and Giles, J.R.: Role of oxidative stress in peripheral inflammatory and neuropathic pain conditions. Society for Neuroscience, 2003.

Shelley, B.C., Hanson, M.L., Minus, T.O. and Crisp, T.: Effects of antioxidants on the behavioral manifestations of peripheral nerve injury. American College of Foot and Ankle Surgeons 2003 Annual Meeting and Scientific Seminar. Orlando, FL, 2003.

Hanson, M.L., Minus, T.O., Giles, J.R., Finnerty, E.P. and Crisp, T.: Can antioxidants reverse the behavioral manifestations of peripheral nerve injury? National Student Osteopathic Medical Association (SOMA) Research Conference, Las Vegas, NV, 2002.

Minus, T.O., Hanson, M.L., Giles, J.R., Finnerty, E.P. and Crisp, T.: Does antioxidant pretreatment prevent the onset of neuropathic pain?  National Student Osteopathic Medical Association (SOMA) Research Conference, Las Vegas, NV, 2002.

Crisp, T., Giles, J.R. and Minus, T.O.: Aging, neuropathic pain and oxidative stress. The Pharmacologist 44: 2 (Supplement 1), A58, 2002.

Crisp, T., Minus, T.O., Puderbaugh, A.A. and Giles, J.R.: Effects of aging and oxidative stress on peripheral nerve injury-induced thermal hyperalgesia and tactile-evoked allodynia. 10th World Congress on Pain, International Association for the Study of Pain (IASP), 154, 2002.

Crisp, T., Cruce, W.L.R., Lovell, J.A., McBurney, D.L. and Stuesse, S.L.: Age-related differences in the behavioral responses of rats to two models of peripheral nerve injury. Society for Neuroscience, 2001.

Stuesse, S.L., Doane, K.J., Lovell, J.A., Crisp, T. and Cruce, W.L.R.: Aging affects the central nervous system response to peripheral nerve injury. Society for Neuroscience, 2001.

Crisp, T., Cruce, W.L.R., McBurney, D.L., Lovell, J.A. and Stuesse, S.L.: Effect of age on the development of thermal and tactile hyperalgesia after a peripheral nerve injury in rats.  Society for Neuroscience, 26: 435, 2000.

Stuesse, S.L., Cruce, W.L.R., McBurney, D.L., Lovell, J.A. and Crisp, T.: Age-related effects of chronic constriction nerve injury (CCI) on astrocytic proliferation in the spinal cord in rats.  Society for Neuroscience,  26: 1894, 2000.

Schechter, J.B., Cruce, W.L.R., McBurney, D.L., Stuesse, S.L. and Crisp, T.: The effect of the synthetic cannabinoid HU-210 on rat learning and spinal nociception.  Society for Neuroscience, 26: 2162, 2000.

Tall, J.M., Stuesse, S.L., Cruce, W.L.R. and Crisp, T.: Gender differences in response to nociceptive stimuli in models of inflammatory and neuropathic pain.  Society for Neuroscience,  26: 437,  2000.

Lovell, J.A., Novak, J.C., Cruce, W.L.R., Stuesse, S.L. and Crisp, T.: Oxidative stress in the spinal cord of rats: effects of aging and peripheral nerve injury.  Soc. Neurosci.,  26: 1212, 2000.

Cruce, W.L.R., McBurney, D.L., Lovell, J.A., Crisp, T. and Stuesse, S.L.: Correlation of behavioral manifestations of sciatic nerve injury with increases in the substance P receptor, NK1, in the spinal cord of rats.  Soc. Neurosci.,  26: 659, 2000.

Block, C.H., Tall, J.M., Crisp, T., Cruce, W.L.R. and Stuesse, S.L.: Microglial proliferation in the spinal cord of rats is influenced by gonadal hormonal status. Soc. Neurosci.,  26, 1943, 2002.

Cruce, W.L.R., Stuesse, S.L., Schechter, J.B., McBurney, D.L., Lovell, J.A. and Crisp, T.: Effect of age on NK-1 receptor density and distribution in the spinal cord of rats with peripheral nerve injury.  Soc. Neurosci., 25; 680, 1999.

Schechter, J.B., Tall, J.M., Stuesse, S.L., Cruce, W.L.R., McBurney, D.L. and Crisp, T.: The antihyperalgesic and antiallodynic efficacy of intrathecal R(+)-methanandamide in the rat. Soc. Neurosci., 25: 1197, 1999.

Lovell, J.A., Novak, J.C., Stuesse, S.L., Cruce, W.L.R. and Crisp, T.: Age-related differences in neuropathic pain and spinal biogenic amines. Soc. Neurosci., 25: 1672, 1999.

Tall, J.M., Stuesse, S.L., Cruce, W.L.R. and Crisp, T.: Steroid hormones alter the behavioral manifestations of chronic neuropathic pain.  Soc. Neurosci., 25: 686, 1999.

Novak, J.C., Stuesse, S.L., Lovell, J.A., Cruce, W.L.R. and Crisp, T.: Effect of age on tyrosine hydroxylase immunoreactivity in the spinal cord of rats with peripheral nerve injury. Soc. Neurosci., 25: 1677, 1999.

Lovell, J.A., Novak, J.C., Ayers, B., Stuesse, S.L., Cruce, W.L.R. and Crisp, T.: Age-related changes in spinal biogenic amine levels following the induction of peripheral nerve injury. The FASEB Journal, 13: A804, 1999.

Novak, J.C., Lovell, J.A., Bailey, C.M., Stuesse, S.L., Cruce, W.L.R. and Crisp, T.: The effects of aging on peripheral nerve injury-induced thermal hyperalgesia and tactile-evoked allodynia.  The FASEB Journal, 13: A803, 1999..

Tall, J.M., Lovell, J.A., Schechter, J.B., Stuesse, S.L., Cruce, W.L.R. and Crisp, T.: Gender-related differences in thermally-mediated hyperalgesia and tactile-evoked allodynia following peripheral nerve injury.  The FASEB Journal, 13: A803, 1999.

Stuesse, S.L., Cruce, W.L.R., Lovell, J.A., Schechter, J.B., McBurney, D.L., Tall, J.M. and Crisp, T.: Effect of age on glial responses in a model of neuropathic pain.   The FASEB Journal, 13: A803, 1999.

Cruce, W.L.R., Lovell, J.A., Stuesse, S.L., Schechter, J.B., McBurney, D.L., Tall, J.M. and Crisp, T.: Effect of age and peripheral nerve injury on NK1 receptor density in the spinal cord.   The FASEB Journal, 13: A803, 1999.

Crisp, T., Balan, C.M. and Gordon, T.L.: Strain-related differences in the thermal hyperalgesic response to a peripheral neuropathy. The FASEB Journal, 12: A138, 1998.

Hoskins, D.L., Gordon, T.L. and Crisp, T.: The effects of aging on 3H-DAMPGO binding in the brain and spinal cord of male Fischer-344 rats. Soc. Neurosci., 23: 1771, 1997.

Ko, M.L., Gordon, T.L. and Crisp, T.: The effects of aging on spinal cAMP in the rat. Soc. Neurosci., 23, 2357, 1997.

Crisp, T., Hoskins, D.L. and Gordon, T.L.: Aging and spinal excitatory amino acids.  The Pharmacologist, 39: No. 1, 60, 1997.

Gordon, T.L., King, M.A. and Crisp, T.: Effects of aging on hyperalgesia.  The Pharmacologist, 39: No. 1, 61, 1997.

Ko, M.L., Stafinsky, J.L. and Crisp, T.:  The effects of aging on spinal neurochemistry in the rat.  Soc. Neurosci., 21: 1622, 1995.

Hoskins, D.L. and Crisp, T.:  The effects of aging on the binding properties of 3H-naltrindole in the brain and spinal cord of F-344 rats.  Soc. Neurosci., 21: 1357, 1995.

King, M.A., Gordon, T. and Crisp, T.:  The treatment of chronic nerve injury pain with excitatory amino acid antagonists and a nitric oxide synthase inhibitor in young, mature and aged male rats.  Soc. Neurosci., 21: 1588, 1995.

Shah, C.J., Tseng, A.Y.N., Uram, M., King, M.A. and Crisp, T.:  Are there age-related differences in the perception of chronic neuropathic pain?  Ohio Society of Anesthesiology, Columbus, OH, 1995.

Torma, J., Hoskins, D.L., Uram, M., Perni, V.C. and Crisp, T.:  The effects of aging on opioid binding sites.  Ohio Society of Anesthesiology, Columbus, OH, 1995.

Tseng, A.Y.N., Uram, M., Perni, V.C. and Crisp, T.:  Postoperative gynecological pain is reduced with naproxen pretreatment.  Ohio Society of Anesthesiology, Columbus, OH, 1995.

Wilson, J.E., Crisp, T., Hoskins, D.L. and Narain, V.:  Pharmacological interactions of gllucagon and beta-blockers in rat lung tissue.  Academic Emergency Medicine, 2: Number 5, 457, 1995.

King, M.A., Ko, M.L., Stafinsky, J.L. and Crisp, T.:  The effects of aging on the antinociceptive properties of DAMPGO, DPDPE or morphine sulfate following intracerebroventricular (i.c.v.) administration in the rat.  Soc. Neurosci., 20: 751, 1994.

Keck, B.J., Stafinsky, J.L. and Crisp, T.:  The effects of chronic intracerebroventricular administration of selective opioid receptor antagonists.  Soc. Neurosci., 20: 749, 1994.

Crisp, T., Stafinsky, J.L., Hoskins, D.L. and Uram, M.:  The effects of aging on spinal opiate-induced antinociception.  7th World Congress on Pain, Paris, France, 1993.

Keck, B.J., Stafinsky, J.L. and Crisp, T.:  The effects of chronic spinal administration of selective opioid antagonists.  Soc. Neurosci., 19: 1153, 1993.

Hoskins, D.L., Stafinsky, J.L. and Crisp, T.:  The effects of aging on spinal opioid-induced antinociception.  Soc. Neurosci., 19: 1553, 1993.

Smith, D.J., Monroe, P.J., Crisp, T. and Smith, D.L.:  Interactions of serotonergic, noradrenergic and opioid neuronal systems in spinal analgesia.  Soc. Neurosci., 19: 523, 1993.

Crisp, T., Stafinsky, J.L., Uram, M. and Perni, V.C.:  The effects of aging on spinal DAMPGO-induced antinociception.  Soc. Neurosci., 18: 1021, 1992.

Crisp, T., Stafinsky, J.L. and Uram, M.:  The role of spinal α-adrenoceptors in opiate antinociception.  The Pharmacologist 34: No. 3, 191, 1992.

Crisp, T., Uram, M., Sivaskandan, U.D. and Stafinsky, J.L.:  Serotonin does not contribute to the antinociceptive effects of fentanyl administered intrathecally or intracerebroventricularly.  The Pharmacologist 33: No.3, 137, 1991.

Stafinsky, J.L. and Crisp, T.:  Changes in spinal opiate-induced antinociception as a function of age. The Pharmacologist 33: No.3, 140, 1991.

Sivaskandan, U.D., Stafinsky, J.L. and Crisp, T.:  The role of norepinephrine in DAMPGO-induced antinociception.  Soc. Neurosci. 17: 1563, 1991.

Crisp, T., Stafinsky, J.L., Perni, V.C., and Uram, M.:  The norepinephrine component contributing to spinal fentanyl-induced analgesia is supraspinally-mediated.  The Pharmacologist 32: No. 3, 138, 1990.

Stafinsky, J.L., Uram, M., Perni, V.C. and Crisp, T.: Alterations in spinal morphine-induced analgesia as a function of pre- versus post-treatment with serotonin receptor antagonists.  The Pharmacologist 32: No. 3, 115, 1990.

Spanos, L.J., Uram, M., Stafinsky, J.L. and Crisp, T.: Systemically-administered oxytocin inhibits intrathecal morphine-induced tolerance development in rats. American Pain Society, St. Louis, Missouri, 1990.

Crisp, T., Stafinsky, J.L., Uram, M. and Spanos, L.J.: A comparative analysis of the monoamine involvement in spinal opiate-induced analgesia.  Intraspinal Narcotics/Pain Update, Open Research Forum, Kauai, Hawaii, 1990.

Monroe, P.J. Perschke, S.E., Crisp, T. and Smith, D.J.:  Evaluation of the interactions of serotonergic ligands with mu, kappa and delta opiate binding sites.  Soc. Neurosci. 16: 851, 1990.

Crisp, T., Stafinsky, J.L., Donepudi, H.B., Perni, S.C. and Spanos, L.J.: Spinal serotonin-induced elevations in hot plate latency are reversed by the 5-HT2 antagonist ritanserin. VI World Congress on Pain, Pain (Suppl.) 5, S162, 1990.

Crisp, T., Stafinsky, J.L., Uram, M. and Perni, V.C.: Intrathecal receptor-selective serotonin (5-HT) agonists differentially affect tail-flick and hot plate nociception.  The Pharmacologist, 31: No. 3 127, 1989.

Stafinsky, J.L., Crisp, T. and Schechter, M.D.: The antinociceptive effects of 3,4-methylenedioxymethamphetamine (MDMA) are serotonergically mediated.  The Pharmacologist, 31: No. 3 127, 1989.

Crisp, T., Stafinsky, J.L., Uram, M. and Perni, V.C.: The involvement of norepinephrine (NE) and serotonin (5-HT) in morphine and fentanyl-induced spinal analgesia.  Soc. Neurosci., 15: 548, 1989.

Spanos, L.J., Stafinsky, J.L. and Crisp, T.: The spinal analgesic properties of the mu (µ) agonist, DAMPGO, in acute and chronic pain.  Soc. Neurosci., 15: 370, 1989.

Smith, D.J., Pekoe, G.M., Monroe, P.J., Martin, L.L. and Crisp, T.: Ketamine Analgesia and Opiate Receptor Interactions.  Ketamine Symposium, Ann Arbor, MI., 1989.

Boja, J., Crisp, T. and Schechter, M.D.:  MDMA and MDE mediate supraspinal but not spinally mediated analgesia:  Evidence for possible 5-HT involvement.  Soc. Neurosci., 14: 524, 1988.

Crisp, T., Stafinsky, J.L. and Uram, M.:  The role of serotonin (5-HT) and norepinephrine (NE) in the analgesic action of ß-endorphin in the spinal cord.  Soc. Neurosci., 14: 853, 1988.

Smith, D.J., Perrotti, J., Crisp, T. and Smith, D.L.:  Does intrathecal serotonin mimic that released endogenously?  Soc. Neurosci., 14: 853, 1988.

Crisp, T., Stafinsky, J.L. and Uram, M.: Spinal ß-endorphin differentially interacts with spinal monoamine systems to alleviate different types of pain.  American Soc. for Pharmacol. and Exp. Ther., A153, 1988.

Spanos, L.J. and Crisp, T.:  Characterization of the : agonist, DAMPGO, in spinal  antinociception.  American Soc. for Pharmacol. and Exp. Ther., A153, 1988.

Crisp, T., Perrotti, J.M. and Smith, D.J.:  The spinal analgesic action of ketamine involves a local serotonergic component.  The Pharmacologist, 29: No. 3, 137, 1987.

Crisp, T., Perrotti, J.M. and Smith, D.J.:  Spinal  antinociceptive properties of morphine, ketamine, serotonin and norepinephrine.  Society Neurosci., 13: 1592, 1987.

Crisp, T., Perrotti, J.M., Eller, R.W. and Smith, D.J.:  Opiate analgesia in the spinal cord involves a local serotonergic component.  Vth World Congress on Pain, Pain (Suppl.) 4, S44, 1987.

Crisp, T., Smith, D.J., Perrotti, J.M. and Amedro, J.B.:  The  antinociceptive action of intrathecal morphine involves the  activation of a local serotonergic component in the spinal cord.  Soc. Neurosci., 12: 619, 1986.

Smith,  D.J., Perrotti, J.M., Long, J.T. and Crisp, T.:  Opiate receptors in the PAG that mediate descending pain inhibition.  The Pharmacologist, 28: No. 3, 139, 1986.

Crisp, T., Cannon, M.S. and Trulson, M.E.:  Electro-physiological and pharmacological properties of mouse brain dopamine-containing ventral tegmental area neurons recorded in vivo and in vitro.  Soc. Neurosci., 11: 1073, 1985.

Crisp, T., Frederickson, C.J. and Trulson, M.E.:  Single unit activity of serotonin-containing neurons in the nucleus raphe dorsalis, raphe medians and raphe pallidus recorded from mouse brain slices in vitro.  Soc. Neurosci., 10: 220, 1984.

Trulson, M.E. and Crisp, T.:  Role of autoreceptors in regulating the activity of serotonin-containing dorsal raphe neurons in vitro.   Soc. Neurosci., 10: 219, 1984.

Crisp, T. and Trulson, M.E.:  Role of norepinephrine in regulating the activity of serotonin-containing dorsal raphe neurons in vitro.  Federation of American Soc. Exp. Biology, 68th Annual Meeting, St. Louis, Missouri, 1984.

Trulson, M.E. and Crisp, T.:  Calcium regulates the activity of serotonin-containing dorsal raphe neurons in vitro.  Federation of American Soc. Exp. Biology, 68th Annual Meeting, St. Louis, Missouri, 1984.

Crisp, T. and Trulson, M.E.:  Dopamine-containing substantia nigra units are unresponsive to changes in plasma glucose levels induced by dietary factors, glucose infusions or insulin administration in freely moving cats.  Eastern Student Research  Forum, Miami, Florida, 1983.

Crisp, T. and Trulson, M.E.:  Chronic administration of d-amphetamine increases 3H-spiroperidol binding in cat brain.  Soc. Neurosci., 9: 1114, 1983.

Crisp, T. and Trulson, M.E.:  Effects of hallucinogenic drugs on serotonin-containing neurons in the midbrain and medulla of freely moving cats.  American Soc. Pharm. and Exp. Ther., Philadelphia, Pennsylvania, 1983.

Crisp, T. and Trulson, M.E.:  Behavioral effects of serotonergic and dopaminergic drugs in cats following chronic amphetamine administration.  Soc. Neurosci., 8: 359, 1982.

Crisp, T., Howell, G.A., Preusller, D.W. and Trulson, M.E.: Effects of quipazine on raphe unit activity and behavior in freely moving cats.  Soc. Neurosci., 7: 923, 1981.


XIII.  Doctoral and Masters Dissertation/Thesis Committees:

A.  Biomedical Sciences, Kent State University in collaboration with Northeastern Ohio Universities College of Medicine (NEOUCOM)

Pharmacology Program Committee:

  1. Linda J. Spanos, Ph.D., 1990 (T.Crisp, primary advisor)
  2. Usha D. Sivaskandan, M.S., 1992 (T. Crisp, primary advisor)
  3. Betty-Jane Keck, Ph.D., 1994 (T. Crisp, primary advisor)
  4. Michael A. King, Ph.D., 1996 (T. Crisp, primary advisor)
  5. Michael L. Ko, Ph.D., 1997 (T. Crisp, primary advisor)
  6. Daryl L. Hoskins, Ph.D., 1998 (T. Crisp, primary advisor)
  7. John C. Novak, M.S., 2000 (T. Crisp, primary advisor)
  8. Jill M. Tall, Ph.D., 2001 (T.Crisp, primary advisor)
  9. Jason B. Schechter, Ph.D., 2001 (T.Crisp, primary advisor)
  10. Christine M. Balan, Ph.D., (Special Education; T. Crisp, primary advisor)
  11. Kui Xu, Ph.D., 1999
  12. Xuemei Gao, M.S., 2001

Neuroscience Program Committee:

  1. Graham Glynn, Ph.D., 1992
  2. Christine Coussens, Ph.D., 1995
  3. John Lovell, Ph.D., 1993
  4. John Z. Little, Ph.D., 1997
  5. James Martinez, in progress
  6. Daniel Radecki, in progress
  7. Rebecca Russell, in progress

Cellular and Molecular Biology Program Committee:

  1. Liming Wang, Ph.D., 1991
  2. Raka Bhattacharya, Ph.D., 1997
  3. Scott Howell, Ph.D., 1998
  4. Meng Ci (Abby) Don, Ph.D.,  1998
  5. Nicholette Larson, Ph.D., 1998

Physiology Program Committee:

  1. Chao-Yin (Avis) Chen, Ph.D., 1996
  2. Heidi Collins, Ph.D., 1997
  3. Cynthia M. Odenweller, M.S., 1998

B.  Biological Sciences, Kent State University

  1. Jeff W. Clemens, Ph.D., 1990
  2. Ernest Freeman, Ph.D., 1990
  3. Marcia Jarrett, Ph.D., 1992
  4. Hamid Noorbakhsh, Ph.D., 1996
  5. Huaming Shen, Ph.D., 1997
  6. Thomas E. Dudley, Ph.D., 1998

C.  Psychology, Kent State University

  1. David Binsack, Ph.D., 1993
  2. Suzanne M. Meehan, Ph.D., 1996
  3. Cantey Land, Ph.D., 1997

XIV.  Faculty Research Mentor (College of Osteopathic Medicine), Des Moines University

  1. Michelle L. Hanson (DO-05 Summer Research student)
  2. Timothy O. Minus (DO-05 Summer Research student)
  3. Alexia Gillen (DO-06 Summer Research student)
  4. Haseeb Ahmed (DO-07 Summer Research student)
  5. Clifford M. Houseman (DO-07 Summer Research student)
  6. Amber Fopma (D0-08 Summer Research student)
  7. Maureen Stroschein (D0-08 Summer Research student)
  8. Christopher Kelley (DO-11 Summer Research student)
  9. Callina Elgar (DO-11 Summer Research student)
  10. Tasha Beenken (Simpson Undergraduate Student; 2005, 2006)
  11. Kelsea Cannon (Wartburg Undergraduate Student, 2005)
  12. Sara Akre (University of Northern Iowa Undergraduate Student, 2008)

XV. Faculty Research Mentor (College of Podiatric Medicine and Surgery), Des Moines University

  1. Brandon Chad Shelley (DPM-05 Summer Research Fellowship)
  2. Kelley Gillroy (DPM-05 Summer Research Fellowship)
  3. Alicia Teausant (DPM-06 Summer Research Fellowship)
  4. Charles Cibula (DPM-06; 2-years as a Summer Research Fellowship)

XVI.  Des Moines University Research Mentor, Biomedical Sciences Graduate Program

  1. Shannon Egli, Masters Degree candidate, 2007-2010 (T. Crisp and D. Strom, advisors).
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